The expression of the new epididymal luminal protein of PDZ domain containing 1 is decreased in asthenozoospermia.

ABSTRACT: Spermatozoa are not mature until they transit the epididymis where they acquire motility and the ability to fertilize an egg through sequential modifications. The epididymis has three functional regions, caput, corpus, and cauda, and the luminal proteins of the epididymis play important roles in the above modifications. However, the proteins with differential enrichment between the caput and cauda are still largely unknown. To reveal the functions of the caput and cauda during sperm maturation, luminal proteins from caput and cauda of mice were analyzed by isobaric tag for relative and absolute quantitation (iTRAQ). Overall, 128 differentially enriched proteins were found, of which 46 were caput enriched and 82 were cauda enriched. Bioinformatic analysis showed that lipid metabolism was ac

SUBMITTER: Liang AJ 

PROVIDER: S-EPMC5858100 | biostudies-literature | 2018 Mar-Apr

REPOSITORIES: biostudies-literature