Prenatal and postnatal antibiotic exposure influences the gut microbiota of preterm infants in neonatal intensive care units.

ABSTRACT:

Background

To explore the influences of prenatal antibiotic exposure, the intensity of prenatal and postnatal antibiotic exposure on gut microbiota of preterm infants and whether gut microbiota and drug resistant strains in the neonatal intensive care unit (NICU) over a defined period are related.

Methods

Among 28 preterm infants, there were two groups, the PAT (prenatal antibiotic therapy) group (12 cases), and the PAF (prenatal antibiotic free) group (12 cases). Fecal samples from both groups were collected on days 7 and 14. According to the time of prenatal and postnatal antibiotic exposure, cases were divided into two groups, H (high) group (11 cases) and L (low) group (11 cases), and fecal samples on day 14 were collected. Genomic DNA was extracted from the fecal sample

SUBMITTER: Zou ZH 

PROVIDER: S-EPMC5858143 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature