Computational tool for immunotoxic assessment of pyrethroids toward adaptive immune cell receptors.

ABSTRACT:

Background

Pyrethroids have prominently known for their insecticidal actions worldwide, but recent reports as anticancer and antiviral applications gained a lot of interest to further understand their safety and immunotoxicity.

Objective

This encouraged us to carry out our present study to evaluate the interactions of pyrethroids toward adaptive immune cell receptors.

Materials and methods

Type 1 and Type 2 pyrethroids were tested on T (CD4 and CD8) and B (CD28 and CD45) immune cell receptors using Maestro 9.3 (Schrödinger, LLC, Cambridge, USA). In addition, top-ranked tested ligands were too explored for toxicity prediction in rodents using ProTOX tool.

Results

Pyrethroids (specifically type 2) such as fenvalerate (-5.534 kcal/mol: CD8), fluvalinate (-4.644 an

SUBMITTER: Kumar A 

PROVIDER: S-EPMC5858232 | biostudies-literature | 2018 Jan-Mar

REPOSITORIES: biostudies-literature