Bioactive Scaffolds for Regeneration of Cartilage and Subchondral Bone Interface.

ABSTRACT: The cartilage lesion resulting from osteoarthritis (OA) always extends into subchondral bone. It is of great importance for simultaneous regeneration of two tissues of cartilage and subchondral bone. 3D-printed Sr₅(PO₄)₂SiO₄ (SPS) bioactive ceramic scaffolds may achieve the aim of regenerating both of cartilage and subchondral bone. We hypothesized that strontium (Sr) and silicon (Si) ions released from SPS scaffolds play a crucial role in osteochondral defect reconstruction. Methods: SPS bioactive ceramic scaffolds were fabricated by a 3D-printing method. The SEM and ICPAES were used to investigate the physicochemical properties of SPS scaffolds. The proliferation and maturation of rabbit chondrocytes stimulated by SPS bioactive ceramics

SUBMITTER: Deng C 

PROVIDER: S-EPMC5858510 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature