Repetition reveals ups and downs of hippocampal, thalamic, and neocortical engagement during mnemonic decisions.

ABSTRACT: The extent to which current information is consistent with past experiences and our capacity to recognize or discriminate accordingly are key factors in flexible memory-guided behavior. Despite a wealth of evidence linking hippocampal and neocortical computations to these phenomena, many important factors remain poorly understood. One such factor is repeated encoding of learned information. In this experiment, participants completed a task in which study stimuli were incidentally encoded either once or three separate times during high-resolution fMRI scanning. We asked how repetition influenced recognition and discrimination memory judgments, and how this affects engagement of hippocampal and neocortical regions. Repetition revealed shifts in engagement in an anterior (ventral) CA1-thalami

SUBMITTER: Reagh ZM 

PROVIDER: S-EPMC5858562 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature