Circadian Misalignment Increases C-Reactive Protein and Blood Pressure in Chronic Shift Workers.

ABSTRACT: Shift work is a risk factor for inflammation, hypertension, and cardiovascular disease. This increased risk cannot be fully explained by classical risk factors. Shift workers' behavioral and environmental cycles are typically misaligned relative to their endogenous circadian system. However, there is little information on the impact of acute circadian misalignment on cardiovascular disease risk in shift workers, independent of differences in work stress, food quality, and other factors that are likely to differ between night and day shifts. Thus, our objectives were to determine the independent effect of circadian misalignment on 24-h high-sensitivity C-reactive protein (hs-CRP; a marker of systemic inflammation) and blood pressure levels-cardiovascular disease risk factors-in chronic shif

SUBMITTER: Morris CJ 

PROVIDER: S-EPMC5858578 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature