Differential immunological profiles herald magnetic resonance imaging-defined perioperative cerebral infarction.

ABSTRACT:

Background

The perioperative period is associated with a high risk for human ischaemic stroke. Although inflammatory mechanisms are known to have an important role in cerebral infarction in the nonoperative setting, their role in modulating perioperative risk remains unclear.

Methods

In this prospective case-control study, we compared 10 patients (cases) who developed magnetic resonance imaging (MRI) evidence of cerebral infarction following transcatheter aortic valve implantation with 10 patients (controls) who underwent the same procedure without neurological complication. Blood sampling was performed preoperatively (baseline) and at 24 h, 48 h and 72 h postoperatively and analysed for specific cytokines, chemokines and complement factors.

Results

Baseline serum ass

SUBMITTER: Fanning JP 

PROVIDER: S-EPMC5858684 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature