MiRNAs as drivers of TMPRSS2-ERG negative prostate tumors in African American men.

ABSTRACT: African Americans (AAs) who have PCa typically have more aggressive disease and make up a disproportionate number of the disease deaths, relative to European Americans (EAs). TMPRSS2 translocations, a common event in EA patients, are exploited in diagnostic and prognostic settings, whereas they are diminished in frequency in AA men. Thus, these patients with TMPRSS2 fusion-negative disease represent an under-investigated patient group. We propose that epigenetic events are a significant and alternative driver of aggressive disease in fusion-negative PCa. To reveal epigenetically governed microRNAs (miRNAs) that are enriched in fusion-negative disease and associated with aggressive in AA PCa, we leveraged both our experimental evidence and publically available data. These analyses identifie

SUBMITTER: Yates C 

PROVIDER: S-EPMC5858730 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature