Misreporting of contraceptive hormone use in clinical research participants.

ABSTRACT:

Objective

Researchers traditionally rely on participant self-report for contraceptive use. We hypothesized that self-reported contraceptive use by clinical research participants may disagree with objectively measured hormonal status.

Study design

We enrolled women in Harare, Zimbabwe, aged 18-34, who by self-report had not used hormonal or intrauterine contraception for >30 days, or depot medroxyprogesterone acetate for >10 months, into a study designed to assess biologic changes with contraceptive initiation and use. Blood samples obtained at enrollment and each follow-up visit (N=1630 from 447 participants) were evaluated by mass spectrometry for exogenous hormones. We individually interviewed a subset of participants (n=20) with discrepant self-reported and measured serum

SUBMITTER: Achilles SL 

PROVIDER: S-EPMC5858917 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature