Association of adiposity, telomere length and mortality: data from the NHANES 1999-2002.

ABSTRACT:

Background/objectives

Telomere shortening is associated with age and risk of medical comorbidity. We assessed the relationship between measures of adiposity, leukocyte telomere length, and mortality and whether it is modified by age.

Subjects/methods

Subjects with dual-energy X-ray absorptiometry measures were identified using the National Health and Nutrition Examination Survey 1999-2002. Obesity was categorized using two body fat definitions (BF1%: men ⩾25%; females ⩾35%; BF2% ⩾28% and ⩾38%, respectively), body mass index (BMI) and waist circumference (WC; men ⩾102 cm; females ⩾88 cm). Telomere length relative to standard reference DNA (T/S ratio) was assessed using quantitative PCR. Weighted multivariable regression models evaluated the association of telomere length with

SUBMITTER: Batsis JA 

PROVIDER: S-EPMC5858938 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature