TiO₂ nanoparticles induce omphalocele in chicken embryo by disrupting Wnt signaling pathway.

ABSTRACT: Titanium dioxide nanoparticles (TiO₂ NPs) are among abundantly used metal oxide NPs but their interactions with biomolecules and subsequent embryonic toxicity in higher vertebrates is not extensively reported. Physicochemical interactions of TiO₂ NPs with egg albumen reveals that lower doses of TiO₂ NPs (10 and 25 µg/ml) accounted for higher friccohesity and activation energy but an increment in molecular radii was recorded at higher doses (50 and 100 µg/ml). FTIR analysis revealed conformational changes in secondary structure of egg albumen as a result of electrostratic interactions between egg albumen and TiO₂ NPs. The morphometric data of chicken embryo recorded a reduction at all the doses of TiO₂ NPs, but toxicity and developmenta

SUBMITTER: Patel S 

PROVIDER: S-EPMC5859020 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature