Insight into the interaction of inhaled corticosteroids with human serum albumin: A spectroscopic-based study.

ABSTRACT: It is well known that the safety and efficacy profile of an inhaled cortocosteroid (ICS) is influenced by the pharmacokinetic properties and associated pharmacodynamic effects of the drug. Freely circulating, protein unbound, and active ICS can cause systemic adverse effects. Therefore, a detailed investigation of drug-protein interaction could be of great interest to understand the pharmacokinetic behaviour of corticosteroids and for the design of new analogues with effective pharmacological properties. In the present work, the interaction between some corticosteroids and human serum albumin (HSA) has been studied by spectroscopic approaches. UV-Vis spectroscopy confirmed that all the investigated corticosteroids can bind to HSA forming a protein-drug complex. The intrinsic fluorescence o

SUBMITTER: Pontremoli C 

PROVIDER: S-EPMC5859165 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature