Evaluation of CYP2C9- and VKORC1-based pharmacogenetic algorithm for warfarin dose in Gaza-Palestine.

ABSTRACT:

Aim

To evaluate applicability of CYP2C9*2, *3 and VKORC1-1639G > A based algorithm to predict warfarin stable dose (WSD) in a group of Palestinian patients.

Patients & methods

Warfarin doses were retrospectively calculated for 101 Palestinian patients under warfarin therapy using three models. Performance of the three models was assessed in 47 patients found to take WSD.

Results

Frequency of CYP2C9*2, *3 and VKORC1-1639G > A alleles is 13.6, 0.0 and 46.5% respectively. The international warfarin pharmacogenetics consortium algorithm was more reliable (MAE = 8.9 ± 1.4; R² = 0.350) than both the clinical algorithm (MAE = 10.4 ± 1.4; R² = 0.128;) and the fixed-dose algorithm (MAE = 11.1 ± 1.7).

Conclusion

SUBMITTER: Ayesh BM 

PROVIDER: S-EPMC5859345 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature