Paeoniflorin exerts neuroprotective effects by modulating the M1/M2 subset polarization of microglia/macrophages in the hippocampal CA1 region of vascular dementia rats via cannabinoid receptor 2.

ABSTRACT:

Background

Cerebral hypoperfusion is a pivotal risk factor for vascular dementia (VD), for which effective therapy remains inadequate. Persistent inflammatory responses and excessive chemotaxis of microglia/macrophages in the brain may accelerate the progression of VD. Endocannabinoids are involved in neuronal protection against inflammation-induced neuronal injury. Cannabinoids acting at cannabinoid receptor 2 (CB₂R) can decrease inflammation. Based on the identification of paeoniflorin (PF) as a CB₂R agonist, we investigated the neuroprotective and microglia/macrophages M1 to M2 polarization promoting effects of PF in a permanent four-vessel occlusion rat model.

Methods

One week after surgery, PF was intraperitoneally administered at a dose of 40 mg/k

SUBMITTER: Luo XQ 

PROVIDER: S-EPMC5859430 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature