Identification of key genes and pathways in human clear cell renal cell carcinoma (ccRCC) by co-expression analysis.

ABSTRACT: Human clear cell renal cell carcinoma (ccRCC) is the most common solid lesion within kidney, and its prognostic is influenced by the progression covering a complex network of gene interactions. In our study, we screened differential expressed genes, and constructed protein-protein interaction (PPI) network and a weighted gene co-expression network to identify key genes and pathways associated with the progression of ccRCC (n = 56). Functional and pathway enrichment analysis demonstrated that upregulated differentially expressed genes (DEGs) were significantly enriched in response to wounding, positive regulation of immune system process, leukocyte activation, immune response and cell activation. Downregulated DEGs were significantly enriched in oxidation reduction, monovalent inorganic cat

SUBMITTER: Yuan L 

PROVIDER: S-EPMC5859473 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature