Cell-based reference samples designed with specific differences in microRNA biomarkers.

ABSTRACT: BACKGROUND:We demonstrate the feasibility of creating a pair of reference samples to be used as surrogates for clinical samples measured in either a research or clinical laboratory setting. The reference sample paradigm presented and evaluated here is designed to assess the capability of a measurement process to detect true differences between two biological samples. Cell-based reference samples can be created with a biomarker signature pattern designed in silico. Clinical laboratories working in regulated applications are required to participate in proficiency testing programs; research laboratories doing discovery typically do not. These reference samples can be used in proficiency tests or as process controls that allow a laboratory to evaluate and optimize its measurement systems, moni

SUBMITTER: Pine PS 

PROVIDER: S-EPMC5859499 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature