Exercise-induced increase in brain-derived neurotrophic factor in human Parkinson's disease: a systematic review and meta-analysis.

ABSTRACT:

Background

Animal models of exercise and Parkinson's disease (PD) have found that the physiologic use of exercise may interact with the neurodegenerative disease process, likely mediated by brain derived neurotrophic factor (BDNF). No reviews so far have assessed the methodologic quality of available intervention studies or have bundled the effect sizes of individual studies on exercise-induced effects on BDNF blood levels in human PD.

Research design and methods

We searched MEDLINE, EMBASE, Cochrane Library, PsycINFO and PubMed from inception to June 2017.

Results

Data aggregated from two randomized controlled trials and four pre-experimental studies with a total of 100 ambulatory patients with idiopathic PD (Hoehn/Yahr ≤3) found improvements in BDNF blood concentrat

SUBMITTER: Hirsch MA 

PROVIDER: S-EPMC5859548 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature