Mono-N-protected amino acid ligands stabilize dimeric palladium(ii) complexes of importance to C-H functionalization.

ABSTRACT: Mono-protected amino acid (MPAA) ligands are used in a number of Pd-catalyzed C-H functionalization reactions. MPAAs have been proposed to bind to Pd(ii) via κ²-(N,O) coordination, but such binding has not yet been experimentally validated. Herein, we report the synthesis and detailed characterization of a series of MPAA complexes prepared via cyclopalladation of dimethylbenzylamine in the presence of MPAAs. The isolated complexes exist as μ-carboxylato (MPAA) bridged dimers and feature potential M-M cooperativity and secondary sphere hydrogen bonding. Selective MPAA coordination and relay of stereochemistry, previously suggested to uniquely result from κ²-(N,O) MPAA coordination, are both observed. The isolated MPAA complexes

SUBMITTER: Gair JJ 

PROVIDER: S-EPMC5859881 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature