A meiotic XPF-ERCC1-like complex recognizes joint molecule recombination intermediates to promote crossover formation.

ABSTRACT: Meiotic crossover formation requires the stabilization of early recombination intermediates by a set of proteins and occurs within the environment of the chromosome axis, a structure important for the regulation of meiotic recombination events. The molecular mechanisms underlying and connecting crossover recombination and axis localization are elusive. Here, we identified the ZZS (Zip2-Zip4-Spo16) complex, required for crossover formation, which carries two distinct activities: one provided by Zip4, which acts as hub through physical interactions with components of the chromosome axis and the crossover machinery, and the other carried by Zip2 and Spo16, which preferentially bind branched DNA molecules in vitro. We found that Zip2 and Spo16 share structural similarities to the structure-spe

SUBMITTER: De Muyt A 

PROVIDER: S-EPMC5859969 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature