StereoGene: rapid estimation of genome-wide correlation of continuous or interval feature data.

ABSTRACT:

Motivation

Genomics features with similar genome-wide distributions are generally hypothesized to be functionally related, for example, colocalization of histones and transcription start sites indicate chromatin regulation of transcription factor activity. Therefore, statistical algorithms to perform spatial, genome-wide correlation among genomic features are required.

Results

Here, we propose a method, StereoGene, that rapidly estimates genome-wide correlation among pairs of genomic features. These features may represent high-throughput data mapped to reference genome or sets of genomic annotations in that reference genome. StereoGene enables correlation of continuous data directly, avoiding the data binarization and subsequent data loss. Correlations are computed among nei

SUBMITTER: Stavrovskaya ED 

PROVIDER: S-EPMC5860031 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature