Shared genetic influence on frailty and chronic widespread pain: a study from TwinsUK.

ABSTRACT:

Introduction

frailty is an increased vulnerability to adverse health outcomes, across multiple physiological systems, with both environmental and genetic drivers. The two most commonly used measures are Rockwood's frailty index (FI) and Fried's frailty phenotype (FP).

Material and methods

the present study included 3626 individuals from the TwinsUK Adult Twin Registry. We used the classical twin model to determine whether FI and FP share the same latent aetiological factors. We also investigated the relationship between frailty and chronic widespread musculoskeletal pain (CWP), another holistic age-related condition with significant clinical impact.

Results

FP and FI shared underlying genetic and environmental aetiology. CWP was associated with both frailty measures,

SUBMITTER: Livshits G 

PROVIDER: S-EPMC5860041 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature