Age at Menarche and Incidence of Diabetes: A Prospective Study of 300,000 Women in China.

ABSTRACT: Previous studies of predominantly Western populations have reported inconsistent associations between age at menarche and risk of diabetes. We examined this relationship among Chinese women, who generally experience menarche at a later age than Western women. In 2004-2008, China Kadoorie Biobank recruited 302,632 women aged 30-79 years from 10 areas across China, and recorded 5,391 incident cases of diabetes during 7 years of follow-up among 270,345 women without baseline diabetes, cardiovascular disease or cancer. Cox regression models yielded adjusted hazard ratios for incident diabetes associated with age at menarche. Overall, the mean age at menarche was 15.4 years, and decreased across successive generations. Age at menarche was linearly and inversely associated with incident diabetes

SUBMITTER: Yang L 

PROVIDER: S-EPMC5860078 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature