STK39 blockage by RNA interference inhibits the proliferation and induces the apoptosis of renal cell carcinoma.

ABSTRACT:

Aim

Renal cell carcinoma (RCC), the most frequent type of primary renal malignancies, has a high mortality rate. Serine/threonine kinase 39 (STK39) is associated with various human diseases, including cancers. The current study aimed to investigate the functions of STK39 in RCC.

Materials and methods

STK39 expression levels in RCC and paired normal renal tissue samples were detected by real-time polymerase chain reaction and Western blotting analyses. The biological functions of STK39 were explored in two RCC cell lines with STK39 silence.

Results

STK39 expression was significantly increased in RCC tissues than in normal renal tissues. Suppression of STK39 expression in ACHN and 786-0 cells significantly suppressed cell proliferation and induced cell apoptosis. Consis

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC5860137 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature