FALCON: a toolbox for the fast contextualization of logical networks.

ABSTRACT:

Motivation

Mathematical modelling of regulatory networks allows for the discovery of knowledge at the system level. However, existing modelling tools are often computation-heavy and do not offer intuitive ways to explore the model, to test hypotheses or to interpret the results biologically.

Results

We have developed a computational approach to contextualize logical models of regulatory networks with biological measurements based on a probabilistic description of rule-based interactions between the different molecules. Here, we propose a Matlab toolbox, FALCON, to automatically and efficiently build and contextualize networks, which includes a pipeline for conducting parameter analysis, knockouts and easy and fast model investigation. The contextualized models could then pro

SUBMITTER: De Landtsheer S 

PROVIDER: S-EPMC5860161 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature