Inferring transcriptional logic from multiple dynamic experiments.

ABSTRACT:

Motivation

The availability of more data of dynamic gene expression under multiple experimental conditions provides new information that makes the key goal of identifying not only the transcriptional regulators of a gene but also the underlying logical structure attainable.

Results

We propose a novel method for inferring transcriptional regulation using a simple, yet biologically interpretable, model to find the logic by which a set of candidate genes and their associated transcription factors (TFs) regulate the transcriptional process of a gene of interest. Our dynamic model links the mRNA transcription rate of the target gene to the activation states of the TFs assuming that these interactions are consistent across multiple experiments and over time. A trans-dimensional Ma

SUBMITTER: Minas G 

PROVIDER: S-EPMC5860162 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature