DART: a fast and accurate RNA-seq mapper with a partitioning strategy.

ABSTRACT:

Motivation

In recent years, the massively parallel cDNA sequencing (RNA-Seq) technologies have become a powerful tool to provide high resolution measurement of expression and high sensitivity in detecting low abundance transcripts. However, RNA-seq data requires a huge amount of computational efforts. The very fundamental and critical step is to align each sequence fragment against the reference genome. Various de novo spliced RNA aligners have been developed in recent years. Though these aligners can handle spliced alignment and detect splice junctions, some challenges still remain to be solved. With the advances in sequencing technologies and the ongoing collection of sequencing data in the ENCODE project, more efficient alignment algorithms are highly demanded. Most read mappers

SUBMITTER: Lin HN 

PROVIDER: S-EPMC5860201 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature