IntPred: a structure-based predictor of protein-protein interaction sites.

ABSTRACT:

Motivation

Protein-protein interactions are vital for protein function with the average protein having between three and ten interacting partners. Knowledge of precise protein-protein interfaces comes from crystal structures deposited in the Protein Data Bank (PDB), but only 50% of structures in the PDB are complexes. There is therefore a need to predict protein-protein interfaces in silico and various methods for this purpose. Here we explore the use of a predictor based on structural features and which exploits random forest machine learning, comparing its performance with a number of popular established methods.

Results

On an independent test set of obligate and transient complexes, our IntPred predictor performs well (MCC = 0.370, ACC = 0.811, SPEC = 0.916, SENS = 0.411)

SUBMITTER: Northey TC 

PROVIDER: S-EPMC5860208 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature