Sparse network modeling and metscape-based visualization methods for the analysis of large-scale metabolomics data.

ABSTRACT:

Motivation

Recent technological advances in mass spectrometry, development of richer mass spectral libraries and data processing tools have enabled large scale metabolic profiling. Biological interpretation of metabolomics studies heavily relies on knowledge-based tools that contain information about metabolic pathways. Incomplete coverage of different areas of metabolism and lack of information about non-canonical connections between metabolites limits the scope of applications of such tools. Furthermore, the presence of a large number of unknown features, which cannot be readily identified, but nonetheless can represent bona fide compounds, also considerably complicates biological interpretation of the data.

Results

Leveraging recent developments in the statistical analysi

SUBMITTER: Basu S 

PROVIDER: S-EPMC5860222 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature