Transcriptional Dynamics During Human Adipogenesis and Its Link to Adipose Morphology and Distribution.

ABSTRACT: White adipose tissue (WAT) can develop into several phenotypes with different pathophysiological impact on type 2 diabetes. To better understand the adipogenic process, the transcriptional events that occur during in vitro differentiation of human adipocytes were investigated and the findings linked to WAT phenotypes. Single-molecule transcriptional profiling provided a detailed map of the expressional changes of genes, enhancers, and long noncoding RNAs, where different types of transcripts share common dynamics during differentiation. Common signatures include early downregulated, transient, and late induced transcripts, all of which are linked to distinct developmental processes during adipogenesis. Enhancers expressed during adipogenesis overlap significantly with genetic variants asso

SUBMITTER: Ehrlund A 

PROVIDER: S-EPMC5860264 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature