HUGIn: Hi-C Unifying Genomic Interrogator.

ABSTRACT:

Motivation

High throughput chromatin conformation capture (3C) technologies, such as Hi-C and ChIA-PET, have the potential to elucidate the functional roles of non-coding variants. However, most of published genome-wide unbiased chromatin organization studies have used cultured cell lines, limiting their generalizability.

Results

We developed a web browser, HUGIn, to visualize Hi-C data generated from 21 human primary tissues and cell lines. HUGIn enables assessment of chromatin contacts both constitutive across and specific to tissue(s) and/or cell line(s) at any genomic loci, including GWAS SNPs, eQTLs and cis-regulatory elements, facilitating the understanding of both GWAS and eQTL results and functional genomics data.

Availability and implementation

HUGIn is avail

SUBMITTER: Martin JS 

PROVIDER: S-EPMC5860315 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature