SNP interaction pattern identifier (SIPI): an intensive search for SNP-SNP interaction patterns.

ABSTRACT:

Motivation

Testing SNP-SNP interactions is considered as a key for overcoming bottlenecks of genetic association studies. However, related statistical methods for testing SNP-SNP interactions are underdeveloped.

Results

We propose the SNP Interaction Pattern Identifier (SIPI), which tests 45 biologically meaningful interaction patterns for a binary outcome. SIPI takes non-hierarchical models, inheritance modes and mode coding direction into consideration. The simulation results show that SIPI has higher power than MDR (Multifactor Dimensionality Reduction), AA_Full, Geno_Full (full interaction model with additive or genotypic mode) and SNPassoc in detecting interactions. Applying SIPI to the prostate cancer PRACTICAL consortium data with approximately 21 000 patients, the fo

SUBMITTER: Lin HY 

PROVIDER: S-EPMC5860469 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature