Individual and Population Trajectories of Influenza Antibody Titers Over Multiple Seasons in a Tropical Country.

ABSTRACT: Seasonal influenza epidemics occur year-round in the tropics, complicating the planning of vaccination programs. We built an individual-level longitudinal model of baseline antibody levels, time of infection, and the subsequent rise and decay of antibodies postinfection using influenza A(H1N1)pdm09 data from 2 sources in Singapore: 1) a noncommunity cohort with real-time polymerase chain reaction-confirmed infections and at least 1 serological sample collected from each participant between May and October 2009 (n = 118) and 2) a community cohort with up to 6 serological samples collected between May 2009 and October 2010 (n = 760). The model was hierarchical, to account for interval censoring and interindividual variation. Model parameters were estimated via a reversible jump Markov chain

SUBMITTER: Zhao X 

PROVIDER: S-EPMC5860523 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature