Epigenetic regulation of gene expression in cancer: techniques, resources and analysis.

ABSTRACT: Cancer is a complex disease, driven by aberrant activity in numerous signaling pathways in even individual malignant cells. Epigenetic changes are critical mediators of these functional changes that drive and maintain the malignant phenotype. Changes in DNA methylation, histone acetylation and methylation, noncoding RNAs, posttranslational modifications are all epigenetic drivers in cancer, independent of changes in the DNA sequence. These epigenetic alterations were once thought to be crucial only for the malignant phenotype maintenance. Now, epigenetic alterations are also recognized as critical for disrupting essential pathways that protect the cells from uncontrolled growth, longer survival and establishment in distant sites from the original tissue. In this review, we focus on DNA met

SUBMITTER: Kagohara LT 

PROVIDER: S-EPMC5860551 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature