Measurement Error Due to Patient Flow in Estimates of Intensive Care Unit Length of Stay.

ABSTRACT: Clinical endpoints measured in terms of duration, such as intensive care unit (ICU) length of stay (LOS), are widely used in randomized clinical trials (RCTs) and observational research. In analyses of patient-level data from a recent RCT, in which ICU LOS was the primary endpoint, and in administrative data, we showed that additional ICU time is often accrued by patients after they are deemed ready for discharge. This "immutable" time (which cannot plausibly be altered by interventions under study) varies by day, week, and year, adding on average one-third of a day to total LOS. We then used statistical simulations, informed by the administrative data and RCT, to assess the impact of immutable time on the measurement and statistical comparison of patients' ICU LOS. These simulations demon

SUBMITTER: Harhay MO 

PROVIDER: S-EPMC5860585 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature