PROSPERous: high-throughput prediction of substrate cleavage sites for 90 proteases with improved accuracy.

ABSTRACT:

Summary

Proteases are enzymes that specifically cleave the peptide backbone of their target proteins. As an important type of irreversible post-translational modification, protein cleavage underlies many key physiological processes. When dysregulated, proteases' actions are associated with numerous diseases. Many proteases are highly specific, cleaving only those target substrates that present certain particular amino acid sequence patterns. Therefore, tools that successfully identify potential target substrates for proteases may also identify previously unknown, physiologically relevant cleavage sites, thus providing insights into biological processes and guiding hypothesis-driven experiments aimed at verifying protease-substrate interaction. In this work, we present PROSPERous, a

SUBMITTER: Song J 

PROVIDER: S-EPMC5860617 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature