PlanNET: homology-based predicted interactome for multiple planarian transcriptomes.

ABSTRACT:

Motivation

Planarians are emerging as a model organism to study regeneration in animals. However, the little available data of protein-protein interactions hinders the advances in understanding the mechanisms underlying its regenerating capabilities.

Results

We have developed a protocol to predict protein-protein interactions using sequence homology data and a reference Human interactome. This methodology was applied on 11 Schmidtea mediterranea transcriptomic sequence datasets. Then, using Neo4j as our database manager, we developed PlanNET, a web application to explore the multiplicity of networks and the associated sequence annotations. By mapping RNA-seq expression experiments onto the predicted networks, and allowing a transcript-centric exploration of the planarian int

SUBMITTER: Castillo-Lara S 

PROVIDER: S-EPMC5860622 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature