Grip strength and inflammatory biomarker profiles in very old adults.

ABSTRACT:

Background

weak grip strength (GS) and chronic inflammation have been implicated in the aetiology of sarcopenia in older adults. Given the interrelationships between inflammatory biomarkers, a summary variable may provide better insight into the relationship between inflammation and muscle strength. This approach has not been investigated in very old adults (aged ≥85) who are at highest risk of muscle weakness.

Methods

we used mixed models to explore the prospective association between GS over 5 years in 845 participants in the Newcastle 85+ Study, and inflammatory components identified by principal component analysis (PCA). Cut-offs of ≤27 kg (men) and ≤16 (women) were used to define sub-cohorts with weak and normal GS at each assessment.

Results

PCA identified three

SUBMITTER: Granic A 

PROVIDER: S-EPMC5860623 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature