Heterogeneity in Estimates of the Impact of Influenza on Population Mortality: A Systematic Review.

ABSTRACT: Influenza viruses are associated with a substantial global burden of morbidity and mortality every year. Estimates of influenza-associated mortality often vary between studies due to differences in study settings, methods, and measurement of outcomes. We reviewed 103 published articles assessing population-based influenza-associated mortality through searches of PubMed and Embase, and we identified considerable variation in the statistical methods used across studies. Studies using regression models with an influenza activity proxy applied 4 approaches to estimate influenza-associated mortality. The estimates increased with age and ranged widely, from -0.3-1.3 and 0.6-8.3 respiratory deaths per 100,000 population for children and adults, respectively, to 4-119 respiratory deaths per 100,00

SUBMITTER: Li L 

PROVIDER: S-EPMC5860627 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature