ATLAS: A database linking binding affinities with structures for wild-type and mutant TCR-pMHC complexes.

ABSTRACT: The ATLAS (Altered TCR Ligand Affinities and Structures) database (https://zlab.umassmed.edu/atlas/web/) is a manually curated repository containing the binding affinities for wild-type and mutant T cell receptors (TCRs) and their antigens, peptides presented by the major histocompatibility complex (pMHC). The database links experimentally measured binding affinities with the corresponding three dimensional (3D) structures for TCR-pMHC complexes. The user can browse and search affinities, structures, and experimental details for TCRs, peptides, and MHCs of interest. We expect this database to facilitate the development of next-generation protein design algorithms targeting TCR-pMHC interactions. ATLAS can be easily parsed using modeling software that builds protein structures for training

SUBMITTER: Borrman T 

PROVIDER: S-EPMC5860664 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature