IgG Glycome in Colorectal Cancer.

ABSTRACT:

Purpose

Alternative glycosylation has significant structural and functional consequences on IgG and consequently also on cancer immunosurveillance. Because of technological limitations, the effects of highly heritable individual variations and the differences in the dynamics of changes in IgG glycosylation on colorectal cancer were never investigated before.

Experimental design

Using recently developed high-throughput UPLC technology for IgG glycosylation analysis, we analyzed IgG glycome composition in 760 patients with colorectal cancer and 538 matching controls. Effects of surgery were evaluated in 28 patients sampled before and three times after surgery. A predictive model was built using regularized logistic regression and evaluated using a 10-cross validation procedure

SUBMITTER: Vuckovic F 

PROVIDER: S-EPMC5860729 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature