Risk factors for type 2 diabetes mellitus: An exposure-wide umbrella review of meta-analyses.

ABSTRACT:

Background

Type 2 diabetes mellitus (T2DM) is a global epidemic associated with increased health expenditure, and low quality of life. Many non-genetic risk factors have been suggested, but their overall epidemiological credibility has not been assessed.

Methods

We searched PubMed to capture all meta-analyses and Mendelian randomization studies for risk factors of T2DM. For each association, we estimated the summary effect size, its 95% confidence and prediction interval, and the I2 metric. We examined the presence of small-study effects and excess significance bias. We assessed the epidemiological credibility through a set of predefined criteria.

Results

We captured 86 eligible papers (142 associations) covering a wide range of biomarkers, medical conditions, and die

SUBMITTER: Bellou V 

PROVIDER: S-EPMC5860745 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature