Night Shift Work, Genetic Risk, and Type 2 Diabetes in the UK Biobank.

ABSTRACT:

Objective

To examine the effects of past and current night shift work and genetic type 2 diabetes vulnerability on type 2 diabetes odds.

Research design and methods

In the UK Biobank, we examined associations of current (N = 272,214) and lifetime (N = 70,480) night shift work exposure with type 2 diabetes risk (6,770 and 1,191 prevalent cases, respectively). For 180,704 and 44,141 unrelated participants of European ancestry (4,002 and 726 cases, respectively) with genetic data, we assessed whether shift work exposure modified the relationship between a genetic risk score (comprising 110 single-nucleotide polymorphisms) for type 2 diabetes and prevalent diabetes.

Results

Compared with day workers, all current night shift workers were at higher multivariab

SUBMITTER: Vetter C 

PROVIDER: S-EPMC5860836 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature