Adjudication of Transient Ischemic Attack and Stroke in the Multi-Ethnic Study of Atherosclerosis.

ABSTRACT:

Background

To describe adjudication of transient ischemic attack (TIA) and stroke in an observational study.

Methods

We detail the process used to adjudicate TIA and stroke in the Multi-Ethnic Study of Atherosclerosis (MESA), a large longitudinal cohort study. Two of three vascular neurologists adjudicated each event using specific protocols. We examined the initial agreement, effect of imaging on diagnosis of TIA versus ischemic stroke, and effect of strict and less strict criteria on the number of ischemic stroke subtypes classified as undetermined.

Results

Of 573 adjudicated events over 13.5 years of follow-up, 95 (16.5%) had TIA and 269 (47.0%) had stroke: 211 (78.4%) ischemic, 43 (16.0%) hemorrhagic, and 15 (5.6%) other. Disagreements occurred on 16% of initial a

SUBMITTER: Longstreth WT 

PROVIDER: S-EPMC5860960 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature