The Alternative NF-κB Pathway in Regulatory T Cell Homeostasis and Suppressive Function.

ABSTRACT: CD4⁺Foxp3⁺ regulatory T cells (Tregs) are essential regulators of immune responses. Perturbation of Treg homeostasis or function can lead to uncontrolled inflammation and autoimmunity. Therefore, understanding the molecular mechanisms involved in Treg biology remains an active area of investigation. It has been shown previously that the NF-κB family of transcription factors, in particular, the canonical pathway subunits, c-Rel and p65, are crucial for the development, maintenance, and function of Tregs. However, the role of the alternative NF-κB pathway components, p100 and RelB, in Treg biology remains unclear. In this article, we show that conditional deletion of the p100 gene, nfkb2, in Tregs, resulted in massive inflammation because of impaired suppressive

SUBMITTER: Grinberg-Bleyer Y 

PROVIDER: S-EPMC5860980 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature