Inflammatory Monocytes Drive Influenza A Virus-Mediated Lung Injury in Juvenile Mice.

ABSTRACT: Healthy children are more likely to die of influenza A virus (IAV) infection than healthy adults. However, little is known about the mechanisms underlying the impact of young age on the development of life-threatening IAV infection. We report increased mortality in juvenile mice compared with adult mice at each infectious dose of IAV. Juvenile mice had sustained elevation of type I IFNs and persistent NLRP3 inflammasome activation in the lungs, both of which were independent of viral titer. Juvenile mice, but not adult mice, had increased MCP-1 levels that remained high even after viral clearance. Importantly, continued production of MCP-1 was associated with persistent recruitment of monocytes to the lungs and prolonged elevation of inflammatory cytokines. Transcriptional signatures of re

SUBMITTER: Coates BM 

PROVIDER: S-EPMC5860989 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature