Top-Down Proteomics Enables Comparative Analysis of Brain Proteoforms Between Mouse Strains.

ABSTRACT: Over the past decade, advances in mass spectrometry-based proteomics have accelerated brain proteome research aimed at studying the expression, dynamic modification, interaction and function of proteins in the nervous system that are associated with physiological and behavioral processes. With the latest hardware and software improvements in top-down mass spectrometry, the technology has expanded from mere protein profiling to high-throughput identification and quantification of intact proteoforms. Murine systems are broadly used as models to study human diseases. Neuroscientists specifically study the mouse brain from inbred strains to help understand how strain-specific genotype and phenotype affect development, functioning, and disease progression. This work describes the first applicat

SUBMITTER: Davis RG 

PROVIDER: S-EPMC5861018 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature