Ferumoxytol-enhanced magnetic resonance imaging in acute myocarditis.

ABSTRACT:

Objectives

Ultrasmall superparamagnetic particles of iron oxide (USPIO)-enhanced MRI can detect tissue-resident macrophage activity and identify cellular inflammation within tissues. We hypothesised that USPIO-enhanced MRI would provide a non-invasive imaging technique that would improve the diagnosis and management of patients with acute myocarditis.

Methods

Ten volunteers and 14 patients with suspected acute myocarditis underwent T2, T2* and late gadolinium enhancement (LGE) 3T MRI, with further T2* imaging at 24 hours after USPIO (ferumoxytol, 4 mg/kg) infusion, at baseline and 3 months. Myocardial oedema and USPIO enhancement were determined within areas of LGE as well as throughout the myocardium.

Results

Myocarditis was confirmed in nine of the 14 suspected case

SUBMITTER: Stirrat CG 

PROVIDER: S-EPMC5861394 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature