The prolyl isomerase FKBP25 regulates microtubule polymerization impacting cell cycle progression and genomic stability.

ABSTRACT: FK506 binding proteins (FKBPs) catalyze the interconversion of cis-trans proline conformers in proteins. Importantly, FK506 drugs have anti-cancer and neuroprotective properties, but the effectors and mechanisms underpinning these properties are not well understood because the cellular function(s) of most FKBP proteins are unclear. FKBP25 is a nuclear prolyl isomerase that interacts directly with nucleic acids and is associated with several DNA/RNA binding proteins. Here, we show the catalytic FKBP domain binds microtubules (MTs) directly to promote their polymerization and stabilize the MT network. Furthermore, FKBP25 associates with the mitotic spindle and regulates entry into mitosis. This interaction is important for mitotic spindle dynamics, as we observe increased chromosome instabil

SUBMITTER: Dilworth D 

PROVIDER: S-EPMC5861405 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature