A homologous mapping method for three-dimensional reconstruction of protein networks reveals disease-associated mutations.

ABSTRACT:

Background

One of the crucial steps toward understanding the associations among molecular interactions, pathways, and diseases in a cell is to investigate detailed atomic protein-protein interactions (PPIs) in the structural interactome. Despite the availability of large-scale methods for analyzing PPI networks, these methods often focused on PPI networks using genome-scale data and/or known experimental PPIs. However, these methods are unable to provide structurally resolved interaction residues and their conservations in PPI networks.

Results

Here, we reconstructed a human three-dimensional (3D) structural PPI network (hDiSNet) with the detailed atomic binding models and disease-associated mutations by enhancing our PPI families and 3D-domain interologs from 60,618 structu

SUBMITTER: Huang SH 

PROVIDER: S-EPMC5861491 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature