Spironolactone and Resistant Hypertension in Heart Failure With Preserved Ejection Fraction.

ABSTRACT:

Background

Recent evidence suggests that the mineralocorticoid receptor antagonist spironolactone should be the preferred fourth-line antihypertensive treatment in resistant hypertension (RHTN). Whether spironolactone improves blood pressure (BP) control in heart failure with preserved ejection fraction (HFpEF) and RHTN is unknown.

Methods

We identified patients with RHTN, defined as baseline systolic blood pressure (SBP) between 140 and 160 mm Hg on 3 or more medications, in the Americas cohort of the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist trial, in which patients with HFpEF were randomized to spironolactone vs. placebo. We evaluated the effects of spironolactone vs. placebo on BP reduction in this group and related this to the

SUBMITTER: Rossignol P 

PROVIDER: S-EPMC5861580 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature